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BACE Antibody (S498) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P56817
Clone Names 4101408
Peptide ID 4101408
Additional Information
Gene ID 23621
Other Names Beta-secretase 1, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, BACE, KIAA1149
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7774a was selected from the S498 region of human BACE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BACE1
Synonyms BACE, KIAA1149
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Cellular Location Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface
Tissue Location Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata
Research Areas
Citations (0)

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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.


Xie, J., et al., J. Biol. Chem. 280(14):13824-13832 (2005).He, X., et al., J. Biol. Chem. 280(12):11696-11703 (2005).Huang, X.P., et al., J. Biol. Chem. 279(36):37886-37894 (2004).Chiocco, M.J., et al., J. Biol. Chem. 279(50):52535-52542 (2004).Yang, H.C., et al., J. Neurochem. 91(6):1249-1259 (2004).

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$ 80.00
Cat# BP7774a
(40 western blots)
Availability: In Stock
Bulk Size
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