|Other Names||Connective tissue growth factor, CCN family member 2, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8, CTGF, CCN2, HCS24, IGFBP8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7778c was selected from the Center region of human CTGF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CCN2, HCS24, IGFBP8|
|Function||Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
|Tissue Location||Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested|
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Provided below are standard protocols that you may find useful for product applications.
Connective tissue growth factor (CTGF), a member of the CCN family of secreted matricellular proteins, regulates fibrosis, angiogenesis, cell proliferation, apoptosis, tumor growth, and metastasis.
Li,M.H., Mol. Cancer Res. 6 (10), 1649-1656 (2008)Bogatkevich,G.S., Am. J. Physiol. Lung Cell Mol. Physiol. 295 (4), L603-L611 (2008)Zhang,P., Tohoku J. Exp. Med. 215 (3), 199-206 (2008)
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