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PRKCDBP Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q969G5 |
|---|---|
| Clone Names | 80220167 |
| Gene ID | 112464 |
|---|---|
| Other Names | Protein kinase C delta-binding protein, Cavin-3, Serum deprivation response factor-related gene product that binds to C-kinase, hSRBC, PRKCDBP, SRBC |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7787c was selected from the Center region of human PRKCDBP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CAVIN3 (HGNC:9400) |
|---|---|
| Synonyms | PRKCDBP, SRBC |
| Function | Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface- dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q91VJ2}. Membrane, caveola. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VJ2}. Note=Localizes in the caveolae in a caveolin-dependent manner. |
| Tissue Location | Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PRKCDBP was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this protein in cultured cell lines is strongly induced by serum starvation, and was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein.
References
Lee,J.H., Int. J. Cancer 122 (7), 1573-1584 (2008)Zochbauer-Muller,S., Oncogene 24 (41), 6249-6255 (2005)Xu,X.L., Cancer Res. 61 (21), 7943-7949 (2001)
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