|Other Names||Insulin receptor substrate 2, IRS-2, IRS2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May mediate the control of various cellular processes by insulin.|
|Cellular Location||Cytoplasm, cytosol.|
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This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Barbieri, M., et al. J. Gerontol. A Biol. Sci. Med. Sci. 65(3):282-286(2010)Craig, D.W., et al. Diabet. Med. 26(11):1090-1098(2009)Rikova, K., et al. Cell 131(6):1190-1203(2007)
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