|Other Names||Cytochrome P450 2W1, 11414-, CYPIIW1, CYP2W1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7792c was selected from the Center region of human CYP2W1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).|
|Cellular Location||Endoplasmic reticulum lumen. Cell membrane. Note=About 8% are expressed on the cell surface.|
|Tissue Location||Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors|
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Provided below are standard protocols that you may find useful for product applications.
CYP2W1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
Hanzawa,Y., Drug Metab. Dispos. 36 (2), 349-352 (2008)Karlgren,M., Biochem. Biophys. Res. Commun. 341 (2), 451-458 (2006)
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