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PHLPP2 Antibody (N-term) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP7799a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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PHLPP2 Antibody (N-term) Blocking Peptide - Product info | |
| Primary Accession | Q6ZVD8 |
| Clone Names | 80102173 |
| Calculated MW | 146751 Da |
PHLPP2 Antibody (N-term) Blocking Peptide - Additional info | |
| Gene ID 23035 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP7799a was selected from the N-term region of human PHLPP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
PHLPP2 Antibody (N-term) Blocking Peptide - Protein Information | |
| Name PHLPP2 | |
| Synonyms KIAA0931, PHLPPL | |
| Function Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor | |
| Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus | |
| Tissue Location In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level) | |
PHLPP2 Antibody (N-term) Blocking Peptide - Related products
AP7799a: PHLPP2 Antibody (N-term)
AP7799b: PHLPP2 Antibody (C-term)
RI13966: PHLPP2 predesign siRNA
PHLPP2 Antibody (N-term) Blocking Peptide - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PHLPP2 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1. This protein regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decrease cell proliferation. It also controls the phosphorylation of AKT3.
REFERENCES
Brognard,J., Mol. Cell 25 (6), 917-931 (2007)
