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TESK2 Antibody (Center C225) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96S53 |
|---|---|
| Clone Names | 70319111 |
| Gene ID | 10420 |
|---|---|
| Other Names | Dual specificity testis-specific protein kinase 2, Testicular protein kinase 2, TESK2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7821f was selected from the Center region of human TESK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TESK2 |
|---|---|
| Function | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser- 3'. May play an important role in spermatogenesis. |
| Cellular Location | Nucleus. |
| Tissue Location | Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
TESK2 is a dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. TESK2 phosphorylates cofilin at Ser-3. It may play an important role in spermatogenesis. This nuclear enzyme is thought to be activated by autophosphorylation on Ser-219. Expression is predominantly in testis and prostate, with highest concentrations in nongerminal Sertoli cells.
References
Toshima,J.,J. Biol. Chem. 276 (33), 31449-31458 (2001)Rosok,O., Genomics 61 (1), 44-54 (1999)
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