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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TGF Beta Receptor I Antibody (Center) Blocking peptide   

TGF Beta Receptor I Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P36897
Clone Names 3031408
Peptide ID 3031408
Additional Information
Gene ID 7046
Other Names TGF-beta receptor type-1, TGFR-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ALK-5, ALK5, Serine/threonine-protein kinase receptor R4, SKR4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I, TGFBR1, ALK5, SKR4
Target/Specificity The synthetic peptide sequence is selected from aa 148~163 of human TGFBR1.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ALK5, SKR4
Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction
Tissue Location Found in all tissues examined, most abundant in placenta and least abundant in brain and heart
Research Areas
Citations (0)

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The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).


Itoh, S., et al., J. Biol. Chem. 278(6):3751-3761 (2003).Valcourt, U., et al., J. Biol. Chem. 277(37):33545-33558 (2002).Bourguignon, L.Y., et al., J. Biol. Chem. 277(42):39703-39712 (2002).Jude, E.B., et al., Diabet. Med. 19(6):440-447 (2002).Nagel, D., et al., Biochem. Biophys. Res. Commun. 290(5):1558-1563 (2002).

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$ 80.00
Cat# BP7822c
(40 western blots)
Availability: In Stock
Bulk Size
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