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BCHE Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P06276 |
|---|---|
| Clone Names | 80311206 |
| Gene ID | 590 |
|---|---|
| Other Names | Cholinesterase, Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase, BCHE, CHE1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7829c was selected from the Center region of human BCHE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BCHE |
|---|---|
| Synonyms | CHE1 |
| Function | Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood plasma (at protein level). Present in most cells except erythrocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mutant proteins of BCHE are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.
References
Primo-Parmo S.L., Bartels C.F.Am. J. Hum. Genet. 58:52-64(1996)Primo-Parmo S.L., Lightstone H.Pharmacogenetics 7:27-34(1997) Yen T., Nightingale B.N.Clin. Chem. 49:1297-1308(2003)
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