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Cyclin C (CCNC) Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P24863 |
|---|---|
| Clone Names | 80102160 |
| Gene ID | 892 |
|---|---|
| Other Names | Cyclin-C, SRB11 homolog, hSRB11, CCNC |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7835b was selected from the C-term region of human CCNC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CCNC |
|---|---|
| Function | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. |
| Cellular Location | Nucleus. |
| Tissue Location | Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CCNC is a member of the cyclin family of proteins. This protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II.
References
Katona,R.L., Acta. Biol. Hung. 58 (1), 133-137 (2007)Ohata,N., Int. J. Mol. Med. 18 (6), 1153-1158 (2006)Sinkkonen,L., Nucleic Acids Res. 33 (8), 2440-2451 (2005)
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