|Other Names||Cyclin-C, SRB11 homolog, hSRB11, CCNC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7835b was selected from the C-term region of human CCNC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.|
|Tissue Location||Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain|
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Provided below are standard protocols that you may find useful for product applications.
CCNC is a member of the cyclin family of proteins. This protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II.
Katona,R.L., Acta. Biol. Hung. 58 (1), 133-137 (2007)Ohata,N., Int. J. Mol. Med. 18 (6), 1153-1158 (2006)Sinkkonen,L., Nucleic Acids Res. 33 (8), 2440-2451 (2005)
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