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MARS Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P56192
Clone Names 71228128
Additional Information
Gene ID 4141
Other Names Methionine--tRNA ligase, cytoplasmic, Methionyl-tRNA synthetase, MetRS, MARS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7844b was selected from the C-term region of human MARS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MARS1 (HGNC:6898)
Synonyms MARS
Function Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971).
Cellular Location Cytoplasm, cytosol. Nucleus, nucleolus. Note=Localizes to the nucleolus in proliferative cells but disappears in quiescent cells
Research Areas
Citations (0)
citation

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Background

methionyl-tRNA synthetase belongs to the class I family of tRNA synthetases. It catalyzes the chemical reaction:ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).

References

Kaminska,M., Biochemistry 40 (47), 14309-14316 (2001)Kang,J., J. Biol. Chem. 275 (41), 31682-31688 (2000)Ko,Y.G., J. Cell Biol. 149 (3), 567-574 (2000)Quevillon,S., J. Mol. Biol. 285 (1), 183-195 (1999)

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$ 277.78
Cat# BP7844b
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