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IARS Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P41252 |
|---|---|
| Clone Names | 80118109 |
| Gene ID | 3376 |
|---|---|
| Other Names | Isoleucine--tRNA ligase, cytoplasmic, Isoleucyl-tRNA synthetase, IRS, IleRS, IARS |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7845a was selected from the N-term region of human IARS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IARS1 (HGNC:5330) |
|---|---|
| Synonyms | IARS |
| Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol |
| Tissue Location | Expressed in liver and muscle (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. It catalyzes the chemical reaction:ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).
References
Shiba K., Proc. Natl. Acad. Sci. U.S.A. 91:7435-7439(1994)Nichols R.C., Gene 155:299-304(1995)
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