ALDH1A3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P47895 |
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Clone Names | 80305123 |
Gene ID | 220 |
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Other Names | Aldehyde dehydrogenase family 1 member A3, Aldehyde dehydrogenase 6, Retinaldehyde dehydrogenase 3, RALDH-3, RalDH3, ALDH1A3, ALDH6 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7847a was selected from the N-term region of human ALDH1A3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ALDH1A3 |
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Synonyms | ALDH6 {ECO:0000303|PubMed:7698756} |
Function | Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans- 13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9JHW9}. |
Tissue Location | Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein form.
References
Rexer,B.N., Cancer Res. 61 (19), 7065-7070 (2001)Yoshida,A., Eur. J. Biochem. 251 (3), 549-557 (1998)
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