|Other Names||Cytosolic 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1, ALDH1L1, FTHFD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7848b was selected from the C-term region of human ALDH1L1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Highly expressed in liver, pancreas and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.
Hosgood,H.D. III,Carcinogenesis 29 (10), 1938-1943 (2008)Lee,K.M., Hum. Genet. 122 (5), 525-533 (2007)
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