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ALDH3A1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P30838
Clone Names 80305129
Peptide ID 80305129
Additional Information
Gene ID 218
Other Names Aldehyde dehydrogenase, dimeric NADP-preferring, ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1, ALDH3A1, ALDH3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7849a was selected from the N-term region of human ALDH3A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH3A1
Synonyms ALDH3
Function ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P47739}.
Tissue Location High levels in stomach, esophagus and lung; low level in the liver and kidney
Research Areas
Citations (0)

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Background

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. The enzyme is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea.

References

Glatt,H., Arch. Biochem. Biophys. 477 (2), 196-205 (2008)Ekhart,C., Pharmacogenet. Genomics 18 (6), 515-523 (2008)Giebultowicz,J., Acta Pol Pharm 65 (1), 81-84 (2008)

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$ 80.00
Cat# BP7849a
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