ALDH3A1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P30838 |
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Clone Names | 80305129 |
Gene ID | 218 |
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Other Names | Aldehyde dehydrogenase, dimeric NADP-preferring, ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1, ALDH3A1, ALDH3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7849a was selected from the N-term region of human ALDH3A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ALDH3A1 |
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Synonyms | ALDH3 |
Function | ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P47739}. |
Tissue Location | High levels in stomach, esophagus and lung; low level in the liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. The enzyme is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea.
References
Glatt,H., Arch. Biochem. Biophys. 477 (2), 196-205 (2008)Ekhart,C., Pharmacogenet. Genomics 18 (6), 515-523 (2008)Giebultowicz,J., Acta Pol Pharm 65 (1), 81-84 (2008)
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