|Other Names||4-trimethylaminobutyraldehyde dehydrogenase, TMABADH, Aldehyde dehydrogenase E3 isozyme, Aldehyde dehydrogenase family 9 member A1, Gamma-aminobutyraldehyde dehydrogenase, R-aminobutyraldehyde dehydrogenase, ALDH9A1, ALDH4, ALDH7, ALDH9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7850a was selected from the N-term region of human ALDH9A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ALDH4, ALDH7, ALDH9|
|Function||Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.|
|Tissue Location||High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole|
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Provided below are standard protocols that you may find useful for product applications.
ALDH9A1 belongs to the aldehyde dehydrogenase family of proteins. The protein has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.
Cheung,C.L., Hum. Mol. Genet. 18 (4), 679-687 (2009)Vaz,F.M., J. Biol. Chem. 275 (10), 7390-7394 (2000)Lin,S.W., Genomics 34 (3), 376-380 (1996)
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