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ALOX5 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P09917
Clone Names 80311184
Peptide ID 80311184
Additional Information
Gene ID 240
Other Names Arachidonate 5-lipoxygenase, 5-LO, 5-lipoxygenase, ALOX5, LOG5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7856c was selected from the Center region of human ALOX5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALOX5
Synonyms LOG5
Function Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Cellular Location Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association
Research Areas
Citations (0)

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ALOX5 is a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of ALOX5 gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers.


Mahshid,Y., BMC Immunol. 10, 2 (2009)Koeberle,A., J. Med. Chem. 51 (24), 8068-8076 (2008)

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$ 80.00
Cat# BP7856c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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