|Other Names||PC4 and SFRS1-interacting protein, CLL-associated antigen KW-7, Dense fine speckles 70 kDa protein, DFS 70, Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52, PSIP1, DFS70, LEDGF, PSIP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7857b was selected from the C-term region of human PSIP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DFS70, LEDGF, PSIP2|
|Function||Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.|
|Cellular Location||Nucleus. Note=Remains chromatin-associated throughout the cell cycle|
|Tissue Location||Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions|
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Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. PSIP2 is involved in particular in lens epithelial cell gene regulation and stress responses. The protein may play an important role in lens epithelial to fiber cell terminal differentiation and may play a protective role during stress-induced apoptosis.
Hare,S., PLoS Pathog. 5 (1), E1000259 (2009)Brown-Bryan,T.A., Mol. Cancer Res. 6 (8), 1293-1307 (2008)
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