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PSIP2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O75475
Clone Names 71211157
Peptide ID 71211157
Additional Information
Gene ID 11168
Other Names PC4 and SFRS1-interacting protein, CLL-associated antigen KW-7, Dense fine speckles 70 kDa protein, DFS 70, Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52, PSIP1, DFS70, LEDGF, PSIP2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7857b was selected from the C-term region of human PSIP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSIP1
Synonyms DFS70, LEDGF, PSIP2
Function Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Cellular Location Nucleus. Note=Remains chromatin-associated throughout the cell cycle
Tissue Location Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions
Research Areas
Citations (0)

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Background

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. PSIP2 is involved in particular in lens epithelial cell gene regulation and stress responses. The protein may play an important role in lens epithelial to fiber cell terminal differentiation and may play a protective role during stress-induced apoptosis.

References

Hare,S., PLoS Pathog. 5 (1), E1000259 (2009)Brown-Bryan,T.A., Mol. Cancer Res. 6 (8), 1293-1307 (2008)

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$ 80.00
Cat# BP7857b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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