|Other Names||M-phase inducer phosphatase 3, Dual specificity phosphatase Cdc25C, CDC25C|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7862b was selected from the C-term region of human CDC25C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.|
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Provided below are standard protocols that you may find useful for product applications.
CDC25C is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest.
Varmeh,S., Mol. Cancer Ther. 7 (12), 3789-3799 (2008)Long,J.M., Cell Cycle 7 (19), 3062-3073 (2008)Bonnet,J., Cell Cycle 7 (13), 1991-1998 (2008)
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