|Other Names||M-phase inducer phosphatase 3, Dual specificity phosphatase Cdc25C, CDC25C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.|
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Provided below are standard protocols that you may find useful for product applications.
CDC25C is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest.
Varmeh,S., Mol. Cancer Ther. 7 (12), 3789-3799 (2008)Long,J.M., Cell Cycle 7 (19), 3062-3073 (2008)Bonnet,J., Cell Cycle 7 (13), 1991-1998 (2008)
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