|Other Names||COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3, COPS3, CSN3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7863c was selected from the Center region of human COPS3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed. Expressed at high level in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
COPS3 possesses kinase activity that phosphorylates regulators involved in signal transduction. This protein phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation.
Henriksen J., Aagesen T.H., Maelandsmo G.M.,.Oncogene 22:5358-5361(2003)Potocki L., Chen K.-S., Lupski J.R.Genomics 57:180-182(1999)Bech-Otschir D., Kraft R., Huang X.,EMBO J. 20:1630-1639(2001)
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