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ANGPT4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y264 |
|---|---|
| Clone Names | 80311203 |
| Gene ID | 51378 |
|---|---|
| Other Names | Angiopoietin-4, ANG-4, Angiopoietin-3, ANG-3, ANGPT4, ANG3, ANG4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7866a was selected from the N-term region of human ANGPT4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ANGPT4 |
|---|---|
| Synonyms | ANG3, ANG4 |
| Function | Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. |
| Cellular Location | Secreted. |
| Tissue Location | Highly expressed in the lung with much lower levels found in other tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ANGPT4 is a protein with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein functions as an agonist and is an angiopoietin.
References
Valenzuela D.M., Griffiths J.A.. Natl. Acad. Sci. U.S.A. 96:1904-1909(1999)
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