|Other Names||AMP deaminase 3, AMP deaminase isoform E, Erythrocyte AMP deaminase, AMPD3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7869c was selected from the Center region of human AMPD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||AMP deaminase plays a critical role in energy metabolism.|
|Tissue Location||Isoform 1 is the predominant form in skeletal muscle; Isoform 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; Isoform 3 is found in erythrocytes|
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Provided below are standard protocols that you may find useful for product applications.
AMPD3 is a member of the AMP deaminase gene family. This protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. The protein is the erythrocyte (E) isoforms, whereas other family members isoforms predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency.
Mahnke-Zizelman D.K., Eddy R.Biochim. Biophys. Acta 1306:75-92(1996) Yamada Y., Goto H., Wakamatsu N., Ogasawara N.Hum. Mutat. 17:78-78(2001)
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