|Other Names||Estrogen-related receptor gamma, ERR gamma-2, Estrogen receptor-related protein 3, Nuclear receptor subfamily 3 group B member 3, ESRRG, ERR3, ERRG2, KIAA0832, NR3B3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7870c was selected from the Center region of human ESRRG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ERR3, ERRG2, KIAA0832, NR3B3|
|Function||Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.|
|Tissue Location||Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.|
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Provided below are standard protocols that you may find useful for product applications.
ESRRG is an orphan receptor that acts as transcription activator in the absence of bound ligand. This protein binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.
Chen F., Zhang Q., McDonald T.Gene 228:101-109(1999)Heard D.J., Norby P.L.Mol. Endocrinol. 14:382-392(2000)Hong H., Yang L., Stallcup M.R.J. Biol. Chem. 274:22618-22626(1999)
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