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ALDH4A1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P30038
Clone Names 80305132
Peptide ID 80305132
Additional Information
Gene ID 8659
Other Names Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase, ALDH4A1, ALDH4, P5CDH
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7875b was selected from the C-term region of human ALDH4A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH4A1
Synonyms ALDH4, P5CDH
Function Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Cellular Location Mitochondrion matrix.
Tissue Location Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas
Research Areas
Citations (0)

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ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.


Yoon,K.A., J. Hum. Genet. 49 (3), 134-140 (2004)Geraghty,M.T., Hum. Mol. Genet. 7 (9), 1411-1415 (1998)

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$ 80.00
Cat# BP7875b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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