|Other Names||Bcl-2-like protein 10, Bcl2-L-10, Anti-apoptotic protein NrH, Apoptosis regulator Bcl-B, BCL2L10, BCLB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7877c was selected from the Center region of human BCL2L10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.|
|Cellular Location||Mitochondrion. Nucleus membrane|
|Tissue Location||Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
BCL2L10 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of BCL2L10 gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation.
Kolluri,S.K., Cancer Cell 14 (4), 285-298 (2008)Krajewska,M., Clin. Cancer Res. 14 (10), 3011-3021 (2008)Zhai,D., J. Biol. Chem. 283 (15), 9580-9586 (2008)Ke,N., J. Biol. Chem. 276 (16), 12481-12484 (2001)
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