|Other Names||Cytochrome P450 4X1, CYPIVX1, CYP4X1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7885a was selected from the N-term region of human CYP4X1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein Microsome membrane|
|Tissue Location||Expressed in brain, heart and kidney and, at lower levels, in skeletal muscle and liver. In the heart, very high level levels in aorta, but very levels in other heart regions.|
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Provided below are standard protocols that you may find useful for product applications.
CYP4X1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain.
Savas,U., Arch. Biochem. Biophys. 436 (2), 377-385 (2005)Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)Bylund,J., Biochem. Biophys. Res. Commun. 296 (3), 677-684 (2002)
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