|Other Names||Cytochrome P450 26C1, 114--, CYP26C1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7892b was selected from the C-term region of human CYP26C1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Detected in most tissues at very low level.|
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Provided below are standard protocols that you may find useful for product applications.
CYP26C1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.
Rat,E., Birth Defects Res. Part A Clin. Mol. Teratol. 76 (6), 491-498 (2006)Taimi,M., J. Biol. Chem. 279 (1), 77-85 (2004)Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
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