|Other Names||Vitamin D 25-hydroxylase, Cytochrome P450 2R1, CYP2R1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7894b was selected from the C-term region of human CYP2R1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in CYP2R1 gene has been associated with selective 25-hydroxyvitamin D deficiency.
Ramos-Lopez,E., Diabetes Obes Metab 10 (8), 683-685 (2008)Strushkevich,N., J. Mol. Biol. 380 (1), 95-106 (2008)Ramos-Lopez,E., Diabetes Metab. Res. Rev. 23 (8), 631-636 (2007)Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
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