|Other Names||Cytochrome P450 4F12, CYPIVF12, CYP4F12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7895a was selected from the N-term region of human CYP4F12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Microsome membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in small intestine, liver, colon and heart.|
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Provided below are standard protocols that you may find useful for product applications.
CYP4F12 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum.
Dhar,M., J. Lipid Res. 49 (3), 612-624 (2008)Stark,K., Arch. Biochem. Biophys. 441 (2), 174-181 (2005)Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
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