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ALOX5AP Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P20292
Clone Names 80311186
Peptide ID 80311186
Additional Information
Gene ID 241
Other Names Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein, ALOX5AP, FLAP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7897b was selected from the C-term region of human ALOX5AP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FLAP
Function Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Cellular Location Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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ALOX5AP is a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.


Zintzaras,E., Am. J. Epidemiol. 169 (5), 523-532 (2009)Crosslin,D.R., Hum. Genet. 125 (2), 217-229 (2009)Steinhilber,D., Pharm Acta Helv 69 (1), 3-14 (1994)

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$ 80.00
Cat# BP7897b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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