|Other Names||Cytochrome P450 3A7, CYPIIIA7, Cytochrome P450-HFLA, CYP3A7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7898a was selected from the N-term region of human CYP3A7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
CYP3A7 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1.
Crettol,S., Ther Drug Monit 30 (6), 689-699 (2008)Hosgood,H.D. III,Carcinogenesis 29 (10), 1938-1943 (2008)Goodarzi,M.O., J. Clin. Endocrinol. Metab. 93 (7), 2909-2912 (2008)
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