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GCK Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P35557
Clone Names 4012126
Peptide ID 4012126
Additional Information
Gene ID 2645
Other Names Glucokinase, Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D, GCK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7901a was selected from the N-term region of human GCK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GCK
Function Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Cellular Location Cytoplasm. Nucleus. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus
Tissue Location Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver
Research Areas
Citations (0)

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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in the gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), also called maturity onset diabetes of the young, type 2 (MODY2); mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).


Gloyn, A.L., et al., Diabetes 52(9):2433-2440 (2003).Pruhova, S., et al., Diabetologia 46(2):291-295 (2003).Rizzo, M.A., et al., J. Biol. Chem. 277(37):34168-34175 (2002).Cao, H., et al., Hum. Mutat. 20(6):478-479 (2002).Barrio, R., et al., J. Clin. Endocrinol. Metab. 87(6):2532-2539 (2002).

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$ 80.00
Cat# BP7901a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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