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LOK Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O94804
Clone Names 2040804
Peptide ID 2040804
Additional Information
Gene ID 6793
Other Names Serine/threonine-protein kinase 10, Lymphocyte-oriented kinase, STK10, LOK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7903a was selected from the C-term region of human LOK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STK10
Synonyms LOK
Function Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
Cellular Location Cell membrane; Peripheral membrane protein
Tissue Location Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.
Research Areas
Citations (0)

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This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.


Kuramochi, S., et al., Immunogenetics 49(5):369-375 (1999).

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$ 80.00
Cat# BP7903a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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