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ASK1 (MEKK5/MAP3K5) Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q99683
Clone Names 2030804
Additional Information
Gene ID 4217
Other Names Mitogen-activated protein kinase kinase kinase 5, Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, MAP3K5, ASK1, MAPKKK5, MEKK5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7911a was selected from the C-term region of human MEKK5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K5
Synonyms ASK1, MAPKKK5, MEKK5
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Cellular Location Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region
Tissue Location Abundantly expressed in heart and pancreas.
Research Areas
Citations (0)
citation

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Background

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that an MEKK5 transcript is abundantly expressed in human heart and pancreas. The MEKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MEKK5 does not activate MAPK/ERK. Check the site for more info: http://biocarta.com/pathfiles/h_mapkPathway.asp

References

Song, J.J., et al., J. Biol. Chem. 278(47):47245-47252 (2003).Yuan, Z.Q., et al., J. Biol. Chem. 278(26):23432-23440 (2003).Zhang, R., et al., J. Clin. Invest. 111(12):1933-1943 (2003).Ohiro, Y., et al., Mol. Cell. Biol. 23(1):322-334 (2003).Galvan, V., et al., J. Biol. Chem. 278(15):13325-13332 (2003).

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$ 277.78
Cat# BP7911a
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