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SGK2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HBY8 |
|---|---|
| Clone Names | 2032507 |
| Gene ID | 10110 |
|---|---|
| Other Names | Serine/threonine-protein kinase Sgk2, Serum/glucocorticoid-regulated kinase 2, SGK2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7947a was selected from the N-term region of human SGK2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SGK2 |
|---|---|
| Function | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Highly expressed in liver, kidney and pancreas, and at lower levels in brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SGK2, a Ser/Thr protein kinase, is similar to serum- and glucocorticoid-induced protein kinase (SGK), but this gene product is not induced by serum or glucocorticoids. Expression is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK.
References
Friedrich, B., et al., Pflugers Arch. 445(6):693-696 (2003).Embark, H.M., et al., Pflugers Arch. 445(5):601-606 (2003).Gamper, N., et al., Pflugers Arch. 445(1):60-66 (2002).Lang, F., et al., Sci. STKE 2001 (108), RE17 (2001).Kobayashi, T., et al., Biochem. J. 344 Pt 1, 189-197 (1999).
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