|Other Names||STE20-like serine/threonine-protein kinase, STE20-like kinase, hSLK, CTCL tumor antigen se20-9, STE20-related serine/threonine-protein kinase, STE20-related kinase, Serine/threonine-protein kinase 2, SLK, KIAA0204, STK2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7951a was selected from the region of human SLK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates apoptosis and actin stress fiber dissolution.|
|Tissue Location||Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
SLK, a member of the serine-threonine kinase family, is activated via homodimerization to signal via ASK1 and p38 to promote apoptosis. Reduction of of the protective endoplasmic reticulum stress response by SLK may contribute to its proapoptotic effect. SLK is proteolytically cleaved by caspase-3.
Eichmuller, S., et al., Proc. Natl. Acad. Sci. U.S.A. 98(2):629-634 (2001).Yamada, E., et al., Biochim. Biophys. Acta 1495(3):250-262 (2000).Sabourin, L.A., et al., Mol. Cell. Biol. 20(2):684-696 (2000).
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