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MAP2K1 Antibody (N-term) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP7960a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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MAP2K1 Antibody (N-term) Blocking Peptide - Product info | |
| Primary Accession | Q02750 |
| Clone Names | 3032110 |
| Calculated MW | 43439 Da |
MAP2K1 Antibody (N-term) Blocking Peptide - Additional info | |
| Gene ID 5604 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP7960a was selected from the N-term region of human MAP2K1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MAP2K1 Antibody (N-term) Blocking Peptide - Protein Information | |
| Name MAP2K1 | |
| Synonyms MEK1, PRKMK1 | |
| Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator- activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis | |
| Cellular Location Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole body. Cytoplasm. Nucleus Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis | |
| Tissue Location Widely expressed, with extremely low levels in brain | |
MAP2K1 Antibody (N-term) Blocking Peptide - Related products
AP3158a: Phospho-MEK1/2-S218/222 Antibody
AP3159a: Phospho-MEK1-S218/222 Antibody
AP3317a: Phospho-MAP2K1-S217 Antibody
AP3318a: Phospho-MAP2K1-T291 Antibody
AP3319a: Phospho-MAP2K1-S297 Antibody
AP3320a: Phospho-MAP2K1-T385 Antibody
AP3611a: Phospho-MEK1-pS218 Antibody
AP3612a: Phospho-MEK1-pS222 Antibody
AP7904b: MAP2K1(S218)/MAP2K2 (S216) Antibody
AP7960a: MEK1 (MAP2K1) Antibody (N-term)
AP7960c: MEK1 Antibody (Center)
AP7960d: MEK1 (MAP2K1) Antibody (S218)
AP7960e: MAP2K1 Antibody (T291)
AP7960f: MAP2K1 Antibody (S297)
AP7960g: MAP2K1 Antibody (T385)
AP7960h: MEK1 Antibody (S218/222)
AP7960i: MAP2K1 Antibody (T285)
AP7960j: MAP2K1 Antibody ( S221 )
RI13154: MAP2K1 predesign siRNA
LY10623a: MAP2K1 Over-expression Lysate
BP3158a: Phospho-MEK1/2-S218/222 Antibody Blocking Peptide
BP3159a: Phospho-MEK1-S217/221 Antibody Blocking Peptide
BP3317a: Phospho-MAP2K1-S217 Antibody Blocking Peptide
BP3318a: Phospho-MAP2K1-T291 Antibody Blocking Peptide
BP3319a: Phospho-MAP2K1-S297 Antibody Blocking Peptide
BP3320a: Phospho-MAP2K1-T385 Antibody Blocking Peptide
BP3611a: Phospho-MEK1-pS218 Antibody Blocking Peptide
BP3612a: Phospho-MEK1-pS222 Antibody Blocking Peptide
BP7904b: MEK1 Antibody (S217) Blocking Peptide
BP7960a: MAP2K1 Antibody (N-term) Blocking Peptide
BP7960c: MEK1 Antibody (Center) Blocking Peptide
BP7960d: MAP2K1 Antibody (S217) Blocking Peptide
BP7960e: MAP2K1 Antibody (T291) Blocking Peptide
BP7960f: MAP2K1 Antibody (S297) Blocking Peptide
BP7960g: MAP2K1 Antibody (T385) Blocking Peptide
BP7960h: MEK1 Antibody (S218/222) Blocking Peptide
BP7960i: MAP2K1 Antibody (T285) Blocking Peptide
BP7960j: MAP2K1 Antibody ( S221 ) Blocking Peptide
AJ1468a: MEK1 Antibody (C-term)
AJ1468b: MEK1 Antibody (N-term)
AJ1468c: MEK1 Antibody Phospho (pT286)
MAP2K1 Antibody (N-term) Blocking Peptide - Research Areas
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BACKGROUND
MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
REFERENCES
Zheng, B., et al., Blood 102(3):1019-1027 (2003).Li, S.P., et al., Cancer Res. 63(13):3473-3477 (2003).Zhu, X., et al., J. Neurochem. 86(1):136-142 (2003).Fringer, J., et al., J. Biol. Chem. 278(23):20612-20617 (2003).Witowsky, J.A., et al., J. Biol. Chem. 278(3):1403-1406 (2003).
