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Synthetic peptide
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- BACKGROUND
| Primary Accession | Q9H1R3 |
|---|---|
| Clone Names | 2122508 |
| Peptide ID | 2122508 |
| Gene ID | 85366 |
|---|---|
| Other Names | Myosin light chain kinase 2, skeletal/cardiac muscle, MLCK2, MYLK2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7964a was selected from the N-term region of human MLCK2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MYLK2 |
|---|---|
| Function | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain. |
| Cellular Location | Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils |
| Tissue Location | Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle.
References
Davis, J.S., et al., Cell 107(5):631-641 (2001).Gallagher, P.J., et al., J. Muscle Res. Cell. Motil. 18(1):1-16 (1997).
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