|Other Names||Myosin light chain kinase 2, skeletal/cardiac muscle, MLCK2, MYLK2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7964a was selected from the N-term region of human MLCK2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain.|
|Cellular Location||Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils|
|Tissue Location||Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle.
Davis, J.S., et al., Cell 107(5):631-641 (2001).Gallagher, P.J., et al., J. Muscle Res. Cell. Motil. 18(1):1-16 (1997).
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