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NIK Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99558 |
|---|---|
| Clone Names | 3021011 |
| Gene ID | 9020 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK, MAP3K14, NIK |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7967c was selected from the Center region of human NIK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAP3K14 (HGNC:6853) |
|---|---|
| Function | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon |
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Provided below are standard protocols that you may find useful for product applications.
Background
NIK (mitogen-activated protein kinase kinase kinase 14), a member of the Ser/Thr protein kinase family, binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
References
Andreakos, E., et al., Blood 101(3):983-991 (2003).Ninomiya-Tsuji, J., et al., Nature 398(6724):252-256 (1999).Aronsson, F.C., et al., Hum. Genet. 103(3):340-345 (1998).Lin, X., et al., Mol. Cell. Biol. 18(10):5899-5907 (1998).Malinin, N.L., et al., Nature 385(6616):540-544 (1997).
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