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KHS2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8IVH8
Other Accession NP_003609
Clone Names 3021811
Additional Information
Gene ID 8491
Other Names Mitogen-activated protein kinase kinase kinase kinase 3, Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, MAP4K3, RAB8IPL1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7972b was selected from the C-term region of human KHS2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP4K3
Synonyms RAB8IPL1
Function May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Tissue Location Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver
Research Areas
Citations (0)
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Background

KHS2, a member of the Ste20 subfamily of Ser/Thr protein kinases, feeatures the characteristic N-terminal catalytic domain and C-terminal regulatory domain of the Ste20 subfamily. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).

References

Diener, K., et al., Proc. Natl. Acad. Sci. U.S.A. 94(18):9687-9692 (1997).

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$ 277.78
Cat# BP7972b
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