KHS2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IVH8 |
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Other Accession | NP_003609 |
Clone Names | 3021811 |
Gene ID | 8491 |
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Other Names | Mitogen-activated protein kinase kinase kinase kinase 3, Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, MAP4K3, RAB8IPL1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7972b was selected from the C-term region of human KHS2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MAP4K3 |
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Synonyms | RAB8IPL1 |
Function | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. |
Tissue Location | Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
KHS2, a member of the Ste20 subfamily of Ser/Thr protein kinases, feeatures the characteristic N-terminal catalytic domain and C-terminal regulatory domain of the Ste20 subfamily. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).
References
Diener, K., et al., Proc. Natl. Acad. Sci. U.S.A. 94(18):9687-9692 (1997).
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