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STC1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P52823
Clone Names 6010974
Additional Information
Gene ID 6781
Other Names Stanniocalcin-1, STC-1, STC1, STC
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7977c was selected from the Center region of human STC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STC1
Synonyms STC
Function Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
Cellular Location Secreted.
Tissue Location Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla
Research Areas
Citations (0)
citation

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Background

STC1 is a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. It contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. This protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate.

References

Law,A.Y., Exp. Cell Res. 314 (16), 2975-2984 (2008)Holmes,D.I., Cell. Signal. 20 (3), 569-579 (2008)Chang,A.C., Genomics 47 (3), 393-398 (1998)

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$ 277.78
Cat# BP7977c
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