|Other Names||Stanniocalcin-1, STC-1, STC1, STC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7977c was selected from the Center region of human STC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.|
|Tissue Location||Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla|
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Provided below are standard protocols that you may find useful for product applications.
STC1 is a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. It contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. This protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate.
Law,A.Y., Exp. Cell Res. 314 (16), 2975-2984 (2008)Holmes,D.I., Cell. Signal. 20 (3), 569-579 (2008)Chang,A.C., Genomics 47 (3), 393-398 (1998)
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