Tiparp Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8C1B2 |
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Clone Names | 71113043 |
Gene ID | 99929 |
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Other Names | TCDD-inducible poly [ADP-ribose] polymerase, ADP-ribosyltransferase diphtheria toxin-like 14, ARTD14, Tiparp |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7978a was selected from the N-term region of human Tiparp . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Tiparp {ECO:0000303|PubMed:11716501, ECO:0000312|MGI:MGI:2159210} |
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Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP- ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable). |
Cellular Location | Nucleus. |
Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.
References
Schmahl,J., Nat. Genet. 39 (1), 52-60 (2007)Ma,Q., Arch. Biochem. Biophys. 404 (2), 309-316 (2002)Ma,Q., Biochem. Biophys. Res. Commun. 289 (2), 499-506 (2001)
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