|Other Names||Tolloid-like protein 2, 3424-, TLL2, KIAA0932|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7983a was selected from the N-term region of human TLL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
TLL2 is an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.
Scott,I.C., Dev. Biol. 213 (2), 283-300 (1999)
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