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QARS Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P47897 |
|---|---|
| Clone Names | 71228135 |
| Gene ID | 5859 |
|---|---|
| Other Names | Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS, QARS |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7986a was selected from the N-term region of human QARS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | QARS1 (HGNC:9751) |
|---|---|
| Synonyms | QARS |
| Function | Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). |
| Cellular Location | Cytoplasm, cytosol. Cytoplasm |
| Tissue Location | Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family.
References
Ko,Y.G., J. Biol. Chem. 276 (8), 6030-6036 (2001)Kang,J., J. Biol. Chem. 275 (41), 31682-31688 (2000)Ko,Y.G., J. Cell Biol. 149 (3), 567-574 (2000)
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