|Other Names||Urotensin-2, Urotensin II, U-II, UII, UTS2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7987a was selected from the N-term region of human UTS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Highly potent vasoconstrictor.|
|Tissue Location||Brain specific.|
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Provided below are standard protocols that you may find useful for product applications.
UTS2 is a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this protein is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide.
Brailoiu,E., Peptides 29 (5), 721-726 (2008)Cirillo,P., J. Thromb. Haemost. 6 (5), 726-736 (2008)Zoccali,C.Hypertension 51 (2), 326-333 (2008)
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