|Other Names||Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS, FARSB, FARSLB, FRSB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7991a was selected from the N-term region of human FARSB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
FARSB is a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA.
Yu,X.Y., Bioorg. Med. Chem. Lett. 14 (5), 1339-1342 (2004)Vasil'eva,I.A., Biochemistry Mosc. 69 (2), 143-153 (2004)Moor,N., Biochemistry 42 (36), 10697-10708 (2003)
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