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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CYP8A1 Antibody (C-term) Blocking Peptide   

CYP8A1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16647
Clone Names 80311156
Peptide ID 80311156
Additional Information
Gene ID 5740
Other Names Prostacyclin synthase, Prostaglandin I2 synthase, PTGIS, CYP8, CYP8A1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7997b was selected from the C-term region of human CYP8A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CYP8, CYP8A1
Function Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate
Research Areas
Citations (0)

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CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.


Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)

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$ 80.00
Cat# BP7997b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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