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CYP3A43 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9HB55
Clone Names 80311123
Additional Information
Gene ID 64816
Other Names Cytochrome P450 3A43, CYP3A43
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7999a was selected from the N-term region of human CYP3A43. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP3A43
Function Exhibits low testosterone 6-beta-hydroxylase activity.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Tissue Location Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.
Research Areas
Citations (0)
citation

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Background

CYP3A43 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, the protein unknown whether the enzyme is also involved in xenobiotic metabolism.

References

Domanski T.L., Finta C.Mol. Pharmacol. 59:386-392(2001)Westlind A., Malmebo S.Biochem. Biophys. Res. Commun. 281:1349-1355(2001)Cauffiez C., Lo-Guidice J.-M.Hum. Mutat. 23:101-101(2004)

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$ 277.78
Cat# BP7999a
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