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KHS Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y4K4
Clone Names 2032704
Peptide ID 2032704
Additional Information
Gene ID 11183
Other Names Mitogen-activated protein kinase kinase kinase kinase 5, Kinase homologous to SPS1/STE20, KHS, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, MEKKK 5, MAP4K5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8007a was selected from the C-term region of human KHS . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP4K5
Function May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Cellular Location Cytoplasm.
Tissue Location Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate
Research Areas
Citations (0)

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Background

KHS, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress. It appears to act upstream of the JUN N-terminal pathway. KHS interacts with both SH3 domains of the adapter proteins CRK and CRKL. This cytoplasmic protein is ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.

References

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Oehrl, W., et al., Oncogene 17(15):1893-1901 (1998).Tung, R.M., et al., Oncogene 14(6):653-659 (1997).

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$ 80.00
Cat# BP8007a
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